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The Role of Bacterial Toxins in Human Skin Disease

  Purpose

Atopic dermatitis and psoriasis are two skin diseases often associated with bacterial infections and inflammation. Studies indicate that skin cells from these patients may have some changes that make these patients more susceptible to bacterial infections. Inflammatory environment may have an effect on the function of skin cells.

The purpose of this study is to learn more about skin cells (keratinocytes and fibroblasts) and how they regulate skin barrier function. To study this we need to establish skin cells that can be grown in the laboratory. We will use small skin biopsies from patients with atopic dermatitis, psoriasis and healthy people as a source of these cells. Since these skin cells have a limited lifetime when grown in laboratory as part of the project we would like to modify them, which allows them to grow for long time in the research laboratory. Some of the collected skin biopsies and isolated skin cells will be used to examine what gene products they make.

Condition Intervention
Atopic Dermatitis Psoriasis Procedure: blood draw/skin biopsy

Study Type: Observational
Study Design:Observational Model: Case Control
Time Perspective: Prospective
Official Title:The Role of Bacterial Toxins in Human Skin Disease

Resource links provided by NLM:

Further study details as provided by Donald Leung, MD, PhD, National Jewish Health:

Primary Outcome Measures:

  • To determine the molecular mechanisms by which cytokines in atopic dermatitis skin alters differentiation of skin keratinocytes [ Time Frame: one year ]

Estimated Enrollment:100
Study Start Date:September 2016
Estimated Study Completion Date:September 2020
Estimated Primary Completion Date:September 2018 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
atopic dermatitis

up to 40 subjects with atopic dermatitis will be enrolled into study.
Procedure: blood draw/skin biopsy
psoriasis

up to 20 subjects with psoriasis will be enrolled into study.
Procedure: blood draw/skin biopsy
people without skin conditions

Up to 40 subjects without skin conditions will be enrolled into study.
Procedure: blood draw/skin biopsy

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