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Psoriasis

Here you will find the latest clinical research on psoriasis.

Effect of Calcipotriol Plus Betamethasone Dipropionate Gel on the HPA Axis and Calcium Metabolism in Adolescent Subjects (Aged 12 to 16 Years, 11 Months) With Scalp and Body Psoriasis

  Purpose An international, multi-centre, prospective, non-controlled, open, single-group, 8-week trial in adolescent subjects (aged 12 to 16 years, 11 months) with scalp and body psoriasis. Condition Intervention Phase Psoriasis Vulgaris Drug: LEO 80185 Phase 2 Study Type: Interventional Study Design: Intervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: …

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The Role of Bacterial Toxins in Human Skin Disease

  Purpose Atopic dermatitis and psoriasis are two skin diseases often associated with bacterial infections and inflammation. Studies indicate that skin cells from these patients may have some changes that make these patients more susceptible to bacterial infections. Inflammatory environment may have an effect on the function of skin cells. …

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A First in Human Study to Evaluate Safety, Tolerability, and Pharmacology of PF-06826647 in Healthy Subjects and Subjects With Plaque Psoriasis

  Purpose This first in human study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-06826647 in healthy subjects and subjects with plaque psoriasis. Condition Intervention Phase Plaque Psoriasis Drug: PF-06826647 tablet Drug: PF-06826647 oral suspension Other: Placebo oral solution/suspension Other: Placebo tablet Phase 1 Study Type: …

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The Effect of BMS-986165 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female Patients

  Purpose The purpose of this study is to investigate the effect of BMS-986165 in combination with an oral contraceptive in healthy female patients. Condition Intervention Phase Systemic Lupus Erythematosus Arthritic Psoriasis Psoriasis Inflammatory Bowel Diseases Drug: BMS-986165 Drug: Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 μg ethinyl estradiol) Phase 1 …

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Clinical Characteristics of Importance to Outcome in Patients With Spondyloarthritis

  Purpose The objective of the study is to investigate extra-articular manifestations, pain mechanisms, patient-reported outcomes, comorbidities and association between these conditions in patients with spondyloarthropathy (SpA) treated with Biologics. Further, to assess the predictive value of baseline pain profile on treatment outcome after ≥ 3 months. Condition Spondyloarthropathy Study …

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Korean College of Rheumatology Biologics Registry (KOBIO)

  Purpose We plan to establish a nationwide Biologics Registry (in the form of an inception cohort) to study the safety profiles in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis patients receiving biologic agents.As this registry is to observe the “real world” use of anti-rheumatic treatments under routine clinical practice, …

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Psoriasis-Arthritis & Bone Program (PSARTROS)

  Purpose Purpose and rationale: To define the role of IL-17 as a mediator of structural bone lesions in psoriasis patients and patients with PsA. Primary Objective is the improvement of the PsAMRIS synovitis score baseline vs. week 24. Drug tested is Secukinumab 300 mg administered weekly for 4 weeks, …

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