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Psoriasis

Here you will find the latest clinical research on psoriasis.

Pharmacogenomics Study on Treatment of Psoriasis Vulgaris by Methotrexate

  Purpose To investigate the influence of genetic factors on the curative effect , to find the relationships between genetic variants and the response of Methotrexate to treatment of Psoriasis Vulgaris. Condition Intervention Phase Psoriasis Vulgaris Drug: Methotrexate Phase 2 Study Type: Interventional Study Design: Intervention Model: Single Group AssignmentMasking: …

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A Study to Provide Real-world Evidence on the Treatment Goal Achievement Rate, Adherence to and Utilization Patterns of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in Greece (CONCORDIA)

  Purpose This study estimates the treatment goal achievement rate, depicts the implementation of the Progressive Psoriasis Initiative (PPI) recommendations regarding treatment modifications and transitioning, and assesses patient adherence and persistence with adalimumab therapy in the routine clinical practice in Greece. Condition Moderate to Severe Plaque Psoriasis Study Type: Observational …

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Evaluate the Safety and Tolerability of Calcipotriene Foam, 0.005%, in Pediatric Subjects (Ages 2 to 11 Years, Inclusive) With Mild to Moderate Plaque Psoriasis.

  Purpose Calcipotriene is a vitamin D3 analog that has been used as topical therapy in adult subjects with plaque-type psoriasis since 1993. Calcipotriene foam, 0.005%, was approved in 2010 for the treatment of plaque psoriasis in adults aged 18 years and older. The current study is a multicenter study …

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A Study of PRCL-02 in Healthy Volunteers and Plaque Psoriasis

  Purpose This study consists of three parts: single oral dose escalation in healthy volunteers (Part A), and multiple oral dose escalations in healthy volunteers (Part B) and in participants with chronic plaque psoriasis (Part C) Condition Intervention Phase Psoriasis Drug: PRCL-02 Drug: Placebo Oral Tablet Phase 1 Study Type: …

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A Study of KY1005 in Healthy Volunteers and Volunteers With Psoriasis

  Purpose This is a single and multiple ascending dose, placebo-controlled, double-blind, Phase 1 study to evaluate the safety and tolerability of KY1005 in healthy volunteers and volunteers with mild-to-moderate plaque psoriasis. Condition Intervention Phase Immune System Diseases Drug: KY1005 Drug: Placebo Phase 1 Study Type: Interventional Study Design: Allocation: …

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Psychotherapy for Patients With Psoriasis: Effects in Quality of Life

  Purpose The aim of this study is to determine the benefits of individual psychotherapy on quality of life for people with psoriasis receiving medical treatment versus a control group (awaiting group) treated with medical treatment, without psychotherapy. Condition Intervention Psoriasis Behavioral: Psychotherapy Study Type: Interventional Study Design: Allocation: RandomizedIntervention …

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APremilast After FumaRic Acid Ester Treatment (APART)

  Purpose Patient treatment preference and treatment satisfaction of physicians and patients comparing fumaric acid ester therapy with subsequent apremilast treatment Condition Intervention Psoriasis Drug: Phase I: Fumaric acid esters. Phase II: Apremilast Study Type: Observational Study Design: Observational Model: OtherTime Perspective: Prospective Official Title: Real-world Benefit of Apremilast Treatment …

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The Difference of Microparticles in Patients With Psoriasis Vulgaris Who Received Stelara(Ustekinumab)

  Purpose Background: Psoriasis, a common inflammatory disease, is associated with atherosclerotic vascular diseases, including stroke, myocardial infarction, and impaired microcirculations, among which circulating microparticles play an important role. In severe psoriasis, there are increased endothelial- and platelet- microparticles that are reduced by TNF-α blockers in parallel with clinical improvement. …

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