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Psoriasis

Here you will find the latest clinical research on psoriasis.

Study of the Efficacy of Early Intervention With Secukinumab 300 mg s.c. Compared to Narrow-band UVB in Patients With New-onset Moderate to Severe Plaque Psoriasis (STEPin)

  Purpose The purpose of this study is to determine whether early intervention with subcutaneous (s.c.) secukinumab 300 mg in patients with new-onset moderate to severe plaque psoriasis may lead to prolonged symptom free periods by preventing reactivation of old lesions or ultimately totally hindering the occurrence of new lesions, …

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LEO 90100 Twice Weekly Maintenance Regimen for Psoriasis Vulgaris

  Purpose A phase 3 trial comparing the efficacy and safety of LEO 90100 aerosol foam with the aerosol foam vehicle used twice weekly as long-term maintenance therapy in subjects with psoriasis vulgaris. A 12-month, international, multi-centre, randomised, vehicle controlled, double-blind, 2-arm, parallel group trial. Condition Intervention Phase Psoriasis Vulgaris …

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Swiss Dermatology Network of Targeted Therapies (SDNTT) (SDNTT)

  Purpose The purpose of this study is to evaluate the long-term course of patients with psoriasis and psoriatic-arthritis in systemic treatments such as, methotrexate, cyclosporin A, fumaric acids, acitretin, systemic PUVA, etanercept, infliximab, adalimumab and ustekinumab. A patient will be included at first initiation of the treatment and will …

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PET/CT in Psoriatic Arthritis

  Purpose When patients with psoriasis develop joint pain, it is often hard to decide whether or not the pain is due to psoriatic arthritis (PsA). At this time, doctors use information from the history and physical exam to determine the diagnosis. X-rays, magnetic resonance imaging (MRI) and ultrasound have …

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Spanish Registry of Systemic Treatments in Psoriasis (Biobadaderm)

  Purpose The purpose of Biobadaderm is a to study the safety of systemic therapy in psoriasis. Condition Psoriasis Study Type: Observational [Patient Registry] Study Design: Observational Model: CohortTime Perspective: Prospective Target Follow-Up Duration: 5 Years Official Title: Spanish Registry of Systemic Treatments in Psoriasis Resource links provided by NLM: …

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A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis

  Purpose This study is a phase I, randomised, double blind (sponsor unblinded), placebo-controlled, single ascending dose study GSK2831781 administered by IV. GSK2831781 is a humanized Antibody Dependent Cell Cytotoxicity (ADCC) enhanced monoclonal afucosylated antibody that is specific to the Lymphocyte Activation Gene-3 (LAG-3) protein. This is the first administration …

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Safety and Efficacy of Secukinumab in Mild Psoriasis

  Purpose Mild psoriasis not only progresses to moderate-to-severe psoriasis but also precedes systemic inflammation that leads to psoriatic arthritis and cardiovascular comorbidities. By curing mild psoriasis with a short-term anti- interleukin (IL)-17A treatment, investigators may reduce the costs of treating psoriasis and associated medical conditions, including psoriatic arthritis, cardiovascular …

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