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Here you will find the latest clinical research on psoriasis.

Vascular Inflammation in Psoriasis – Apremilast (VIP-A)

  Purpose The purpose of the VIP-A study is to determine the effect of apremilast on aortic vascular inflammation, cardiometabolic biomarkers and body composition in patients with moderate-severe psoriasis. Condition Intervention Phase Psoriasis Cardiovascular Diseases Drug: Apremilast Phase 4 Study Type: Interventional Study Design: Intervention Model: Single Group AssignmentMasking: None …

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UCB Cimzia Pregnancy Follow-up Study

  Purpose The purpose of this observational follow-up study is to collect data systematically on pregnancies and offspring of women who become pregnant while participating in a Certolizumab Pegol (CZP) study or whose pregnancies have otherwise been reported to UCB due to potential CZP exposure during pregnancy. Condition Rheumatoid Arthritis …

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Tolerability, Safety and Pharmacokinetic Study of Humanized Anti-CD6 Monoclonal Antibody Injection in Chinese Psoriasis

  Purpose The humanized recombinant anti-CD6 monoclonal antibody Injection (T1h) has been approved for psoriasis in India. The first trial in China is to evaluate the tolerability, safety, pharmacodynamic, pharmacokinetics and preliminary efficacy of T1h for patients with psoriasis. Condition Intervention Phase Psoriasis Biological: T1h Phase 1 Study Type: Interventional …

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Role of Tyrosine Kinase Lyn and Cleaved Form by Caspases in Psoriasis

  Purpose Psoriasis is a chronic autoimmune disorder of the skin. In this disease, the inflammatory caspases, cysteine proteases involved in the processing of many proteins, are activated. Transgenic mice expressing the cleaved form of caspases by Lyn, a tyrosine kinase Src family, develop an inflammatory syndrome with the characteristics …

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Safety and Effectiveness of Live Zoster Vaccine in Anti-Tumor Necrosis Factor (TNF) Users (VERVE Trial)

  Purpose The VaricElla zosteR VaccinE (VERVE) trial evaluates the safety and effectiveness of the herpes zoster (shingles) vaccine, Zostavax, in patients over 50 years old with arthritis and other diseases who are using anti-TNF therapy and who have not previously received the vaccine. Condition Intervention Phase Rheumatoid Arthritis Inflammatory …

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Pregnancy and Medically Assisted Conception in Rare Diseases (EGR2)

  Purpose Rare diseases frequently affect women of childbearing age. Pregnancy in these women has become less rare, but remains associated with high levels of complications. One obstacle to their optimal management during pregnancy is that there are no prospective studies of pregnancy during rare diseases and several connective tissue …

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Post-Marketing Surveillance Study of OTEZLA

  Purpose To evaluate the safety and efficacy of OTEZLA in actual clinical settings of use in patients with Psoriasis vulgaris that is with an inadequate response to topical therapies and Psoriasis arthropathica Planned registration period 2 years Planned surveillance period for 4 years from 6 months after launch Condition …

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Study of Ixekizumab (LY2439821) in Children 6 to Less Than 18 Years With Moderate-to-Severe Plaque Psoriasis (Ixora-peds)

  Purpose The purpose of this study is to evaluate the safety and efficacy of ixekizumab in pediatric participants with moderate-to-severe plaque psoriasis. Condition Intervention Phase Plaque Psoriasis Drug: Ixekizumab Drug: Placebo Phase 3 Study Type: Interventional Study Design: Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, …

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