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Here you will find the latest clinical research on psoriasis.

Psoriasis duration linked to cardiovascular disease risk


New research offers strong evidence that vascular inflammation and risk of having a major adverse cardiovascular event, such as heart attack or stroke, increase with psoriasis duration. As a result, dermatologists and other providers should consider asking how long patients have had psoriasis when assessing cardiovascular risk stratification, according to the authors. …

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A Safety Study of Ustekinumab in the Treatment of Pediatric Participants Aged 12 Years and Older With Moderate to Severe Plaque Psoriasis

  Purpose The purpose of this study is to monitor the long-term safety of ustekinumab in pediatric participants (aged greater than or equal to 12 years to less than 18 years inclusive) with moderate to severe plaque psoriasis, through monitoring for the following adverse events potentially related to immune modulation: …

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Secukinumab Therapy for the Treatment of Moderate to Severe Plaque Psoriasis With Response Monitoring Using Optical Coherence Tomography (OCT).

  Purpose This is a phase IV, single-center, open label, single arm study in which a group of 30 subjects with moderate to severe plaque psoriasis will receive secukinumab therapy. Non-invasive imaging with optical coherence tomography (OCT) will be used to monitor the resolution of psoriatic plaques with treatment in …

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A Study to Evaluate BMS-986165 Tablet Formulation Relative to BMS-986165 Capsule Formulation and the Effect of a High-Fat/ High-Calorie Meal and Increased Gastric pH on the BMS-986165 Tablet Formulation

  Purpose The purpose of this study is to evaluate BMS-986165 tablet formulation versus BMS-986165 capsule formulation. This study will also evaluate the effect of a high-fat/ high-calorie meal and increased gastric pH on the BMS-986165 tablet formulation. Condition Intervention Phase Systemic Lupus Erythematosus Arthritic Psoriasis Psoriasis Inflammatory Bowel Diseases …

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A Study to Evaluate the Effectiveness and Patient-Reported Outcome of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in China (ADAPT)

  Purpose The objective of this non-interventional, observational study is to assess the effectiveness and patient reported outcome of adalimumab in patients with moderate to severe psoriasis in real world clinical practice in China. Condition Psoriasis Study Type: Observational Study Design: Observational Model: CohortTime Perspective: Prospective Official Title: Postmarketing Observational …

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Role of Chemokine and Chemokine Receptor in Psoriasis

  Purpose This study aims to elucidate the role of Chemokine and chemokine receptor in the pathogenesis of Psoriasis by using human psoriasis skin xenograft SCID mouse model. The hypothesis is that chemokine and chemokine receptor play important roles in psoriasis and establishment of human skin xenograft mouse model provide …

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A Study to Assess the Efficacy of Risankizumab Compared to FUMADERM® in Subjects With Moderate to Severe Plaque Psoriasis Who Are Naïve to and Candidates for Systemic Therapy

  Purpose The purpose of this study is to compare the efficacy and safety of subcutaneous (SC) risankizumab and oral FUMADERM provided as study medication in subjects with moderate to severe plaque psoriasis who are naïve to and candidates for systemic therapy. Condition Intervention Phase Psoriasis Drug: risankizumab Drug: Fumaderm …

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A Clinical Trial Evaluating Efficacy and Safety of MC2-01 Cream

  Purpose This trial is a randomized, investigator-blind, multicentre, vehicle- and comparator-controlled, parallel-group trial with the purpose of evaluating efficacy, safety and convenience of the MC2-01 cream. Condition Intervention Phase Psoriasis Vulgaris Drug: MC2-01 cream Drug: Cal/BDP combination Drug: Cream vehicle Phase 3 Study Type: Interventional Study Design: Allocation: RandomizedIntervention …

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