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A rationally designed multi-functional antibiotic for the treatment of drug-resistant acne.

DOI: j.jid.2017.11.041  PMID: 29409921   Acne is a multifactorial skin disease, underpinned by colonization of Propionibacterium acnes and inflammation. The emergence of resistant Propionibacterium acnes strains has affected the current acne treatment algorithm. This setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect …

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Propionibacterium acnes-derived extracellular vesicles promote acne-like phenotypes in human epidermis.

DOI: j.jid.2018.01.007  PMID: 29409885   Acne vulgaris is an inflammatory disease occurring in the pilosebaceous unit and is the most common skin condition in young people. A gram-positive bacterium, Propionibacterium acnes (P. acnes), has been suspected to contribute to the development of acne. Here, we report that P. acnes constitutively releases extracellular …

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