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sodium thiosulfate (Rx)

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Dosing & Uses AdultPediatric Dosage Forms & Strengths injection solution 100mg/mL (10%) 250mg/mL (25%) Cyanide Poisoning 12.

IV (infuse over 10-20 minutes) Cisplatin Extravasation 2 mL 1/6 molar solution through IV cannula for every 100 mg cisplatin; remove needle, then inject 0.

L injections clockwise around extravasation area up to 1 mL; repeat several times within the 3-4 hr of extravasation incident Cisplatin Nephrotoxicity 4 g/m² IV bolus followed by 12 g/m² IV infusion over 6 hr Preparation of 1/6 Molar Solution 4 mL of 10% solution + 6 mL sterile water for injection 1.

L of 25% solution + 8.

L sterile water for injection Orphan Designations Calciphylaxis: 25 g IV 3 times per week following dialysis for 6 weeks to 9 months; other protocols exist Mechlorethamine extravasation: 2 mL 10% solution through IV cannula for every 2 mg mechlorethamine extravasated; remove needle, then inject 10 mL of 1/6 molar solution SC Sulfur mustard poisoning Dermatomyositis Orphan sponsor Hope Pharmaceuticals; 16416 N.

Street, Suite 125; Scottsdale, AZ 85260 Administration Monitor for thiocyanate toxicity Dosage Forms & Strengths injection solution 100mg/mL (10%) 250mg/mL (25%) Cyanide Poisoning 7 g/m² IV (maximum 12.

Platinum-Induced Ototoxicity (Orphan) Prevention of platinum-induced ototoxicity in pediatric patients Orphan sponsor Adherex Technologies, Inc; 501 Eastowne Dr Suite 140; Chapel Hill, NC 27514 Hope Pharmaceuticals; 16416 N.

Street Suite 125; Scottsdale, AZ 85260 Next: Adverse Effects Frequency Not Defined Hypotension (infusion rate-dependent) Nausea/vomiting Disorientation Headache Prolonged bleeding therapy Hypersensitivity reactions Contact dermatitis Warmth Local irritation Previous Next: Pregnancy & Lactation Pregnancy Category: C Pregnancy Categories A:Generally acceptable.

Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable.

Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks.

Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available.

Positive evidence of human fetal risk.

X:Do not use in pregnancy.

Risks involved outweigh potential benefits.

Safer alternatives exist.

NA:Information not available.

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