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Consider different etiologies in patients with vaginal pruritus

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CHICAGO – Diagnosing the cause of vaginal itching, which can have a significant negative impact on a woman’s quality of life, can be particularly difficult for multiple reasons, according to Rachel Kornik, MD, of the departments of dermatology and obstetrics and gynecology at the University of Wisconsin, Madison. “The anatomy is really challenging in this …

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Consider different etiologies in patients with vaginal pruritus

kids sun exposure

CHICAGO – Diagnosing the cause of vaginal itching, which can have a significant negative impact on a woman’s quality of life, can be particularly difficult for multiple reasons, according to Rachel Kornik, MD, of the departments of dermatology and obstetrics and gynecology at the University of Wisconsin, Madison. “The anatomy …

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Irritant Contact Dermatitis.

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Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and ACD may have …

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Allergen of the year may be nearer than you think

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MONTEREY, CALIF. – It’s only found in 2%-3% of allergy cases. So why was propylene glycol (PG) declared the Allergen of the Year for 2018 by the North American Contact Dermatitis Society? Because, a dermatologist told colleagues, it’s so common. Dr. Joseph F. Fowler Jr. “If you’re allergic to it, …

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Allergen of the year may be nearer than you think

kids sun exposure

MONTEREY, CALIF. – It’s only found in 2%-3% of allergy cases. So why was propylene glycol (PG) declared the Allergen of the Year for 2018 by the North American Contact Dermatitis Society? Because, a dermatologist told colleagues, it’s so common. Dr. Joseph F. Fowler Jr. “If you’re allergic to it, …

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Isothiazolinone derivatives and allergic contact dermatitis: a review and update.

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Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/ methylisothiazolinone (MCI/MI) in the 1980’s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave-on products, whilst restricting that in …

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Oral ulcer due to dabigatran capsule.

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When evaluating consumer products for safety, one must consider the heterogeneity of the population that might use those products, including the potential for different sensitivity based on factors such as age, gender, and genetics. For both systemic endpoints and allergic contact dermatitis (ACD), quantitative safety evaluations typically include a default …

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Regulatory control of DNA end resection by Sae2 phosphorylation.

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T cells critically depend on reprogramming of metabolic signatures to meet the bioenergetic demands during activation and clonal expansion. Here we identify the transcription factor Nur77 as a cell-intrinsic modulator of T cell activation. Nur77-deficient T cells are highly proliferative, and lack of Nur77 is associated with enhanced T cell …

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