Home / Acne / Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients.

Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients.

PMID: 1357876  

To explore the mechanism by which zinc acts on cutaneous inflammatory lesions, we studied granulocyte zinc levels and in vitro polymorphonuclear leukocyte chemotaxis in 20 acne patients before and after 2 months of zinc therapy (200 mg/day zinc gluconate). The zinc level was assayed by flame absorption spectrophotometry and chemotaxis was performed by agarose assay. After 2 months of treatment, a significant decrease in granulocyte zinc level associated with inhibition of chemotaxis (r = 0.69) was observed in 16 patients. This suggests that zinc anti-inflammatory action is related to inhibition of polymorphonuclear leukocyte chemotaxis induced by a decreased granulocyte zinc level.

Dreno B,  Trossaert M,  Boiteau HL,  Litoux P

About

Check Also

Indicators of phagocytosis in women with acne during comprehensive treatment that included immunotherapy and probiotics.

PMID: 29602922   Introduction: Acne is one of the most common dermatological diseases. It may have …

Leave a Reply

Your email address will not be published. Required fields are marked *