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Two different pathogenetic mechanisms may play a role in acne and in hirsutism.

PMID: 8252744  

Acne is one of the most common skin disorders. Androgens are known to play an important and possibly central role. Androgens secreted from ovaries and adrenal glands (androstenedione, dehydroepiandrosterone and its sulphate, testosterone) and target tissue-produced androgens (testosterone and its 5 alpha-reduced metabolite, dihydrotestosterone) have been implicated. Although the sebaceous gland and the hair follicle form a single morphological entity, the pilosebaceous unit, acne and hirsutism do not always appear concomitantly, thus leading to the supposition that these two structures may have different degrees of sensitivity to similar androgenic stimulation.

Toscano V,  Balducci R,  Bianchi P,  Guglielmi R,  Mangiantini A,  Rossi FG,  Colonna LM,  Sciarra F

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