Home / Acne / Severe acne and hyperandrogenemia following dactinomycin.

Severe acne and hyperandrogenemia following dactinomycin.

PMID: 8388076  

The etiology of dactinomycin-associated acne has not previously been studied. An 81/2 year old girl with embryonal rhabdomyosarcoma of the left petrous bone was prepubertal at the time of presentation. Treatment according to a current Intergroup Rhabdomyosarcoma Study regimen consisted of vincristine, dactinomycin, and cyclophosphamide at 3 to 6 week intervals, as well as hyperfractionated radiotherapy to the tumor bad. Severe acne of the forehead developed within 10 days of starting therapy and resolved over the next 2 months. Serial measurements of serum hormones documented periodic increases in androgen levels coincident with courses of dactinomycin. These observations support a relationship between drug, dermatitis, and hormone levels. Study of other patients will be of interest to document the frequency, degree, and mechanism of hyperandrogenemia following dactinomycin.

Blatt J,  Lee PA


Check Also

Indicators of phagocytosis in women with acne during comprehensive treatment that included immunotherapy and probiotics.

PMID: 29602922   Introduction: Acne is one of the most common dermatological diseases. It may have …

Leave a Reply

Your email address will not be published. Required fields are marked *