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Psychiatric disorders, acne and systemic retinoids: comparison of risks.

DOI: 14740338.2017.1344641  PMID: 28657366  

The link between isotretinoin, treatment of a severe form of acne, and psychiatric disorders remains controversial, as acne itself could explain the occurrence of psychiatric disorders. This study aims at assessing the disproportionality of psychiatric adverse events reported with isotretinoin in the French National PharmacoVigilance Database, compared with other systemic acne treatments and systemic retinoids.

Le Moigne M,  Bulteau S,  Grall-Bronnec M,  Gerardin M,  Fournier JP,  Jonville-Bera AP,  Jolliet P,  Dreno B,  Victorri-Vigneau C

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