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Evaluation of autologous platelet rich plasma plus ablative carbon dioxide fractional laser in the treatment of acne scars.

DOI: 14764172.2017.1368667  PMID: 28853968   Acne scar is a common distressing complication of acne vulgaris. CO2 laser resurfacing proved effective for treatment of such problem but the associated complications may limit its use. Platelet rich plasma (PRP) may increase the chance of favorable outcome. Abdel Aal AM,  Ibrahim IM,  Sami NA,  Abdel Kareem IM

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IL-36 cytokines are increased in acne and hidradenitis suppurativa.

DOI: s00403-017-1769-5  PMID: 28852851   Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in …

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General quality of life of patients with acne vulgaris before and after performing selected cosmetological treatments.

DOI: PPA.S131184  PMCID: PMC5553351  PMID: 28831246   Achieving a satisfying quality of life for a patient by applying individually matched therapy is, simultaneously, a great challenge and a priority for contemporary medicine. Patients with visible dermatological ailments are particularly susceptible to reduction in the general quality of life. Among the dermatological diseases, acne …

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The microbiota matters: In acne, it’s not us versus them

microbiota ance

EXPERT ANALYSIS FROM THE 2017 AAD SUMMER MEETING NEW YORK – Just as an imbalance in the intestinal microbiota can disrupt gut function, dysbiosis of the facial skin can allow acne-causing bacteria to flourish. In acne, said Adam Friedman, MD, “we’ve always been talking about bacteria,” but now the thinking has …

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In vitro anti-acne activity of phytoactives from the stem bark of Artocarpus hirsutus Lam. and characterisation of pyranocycloartobiloxanthone A as a mixture of two anomers.

DOI: 14786419.2017.1365068  PMID: 28820275   This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were …

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Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.

DOI: s12986-017-0212-4  PMCID: PMC5556685  PMID: 28814964   There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regulated gene expression of the transcription factor p53 and DNA methyltransferase 1 (DNMT1), two …

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What is new in the pathophysiology of acne, an overview.

DOI: jdv.14374  PMID: 28805938   Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilosebaceous unit. Recent research has shed some new light on the involvement of the sebaceous gland, as well as on the pro-inflammatory activity of …

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Fragility of epidermis: acne and post-procedure lesional skin.

DOI: jdv.14410  PMID: 28805934   ‘Fragile skin’, or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e.g. stress) and iatrogenic (caused by …

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