Despite the high frequency with which truncal acne accompanies facial acne, patients with truncal acne have fewer effective topical treatments. An investigator-initiated pilot study shows that azelaic acid (AzA) 15 percent foam could provide an appropriate off-label option.1 Azelaic acid foam 15 percent is FDA-approved for rosacea. “On the other …Read More »
Summary Background Acne vulgaris is one of the commonest skin disorders affecting up to 80% of the world population at least during adolescence. Significant psychosocial effects such as depression and poor personality development have been linked with acne, especially in female adolescents. Various causative factors, including cosmetic exposure, have been …Read More »
DOI: s12967-017-1297-2 PMID: 28927457 This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhance p53 expression. Tetracyclines and macrolides via inhibiting p450 enzymes attenuate ATRA degradation, thereby increase p53. Benzoyl peroxide …Read More »
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions.
DOI: internalmedicine.8250-16 PMID: 28924111 We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement …Read More »
DOI: j.jaad.2017.04.1110 PMID: 28917458 Huyler AH, Zaenglein ALRead More »
Efficacy and Safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel in Facial Acne Vulgaris: A Randomized, Controlled Clinical Trial.
DOI: s40261-017-0568-2 PMID: 28913735 Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. Maiti R, Sirka CS, Ashique Rahman MA, Srinivasan A, Parida S, Hota DRead More »
An ecofriendly green liquid chromatographic method for simultaneous determination of nicotinamide and clindamycin phosphate in pharmaceutical gel for acne treatment.
DOI: j.jfda.2016.09.009 PMID: 28911660 A new green micellar liquid chromatographic method was developed and validated for the quantitative estimation of nicotinamide (NICO) and clindamycin phosphate (CLD) in bulk and pharmaceutical gel formulation. The analytes are well resolved in less than 6.0 minutes using micellar mobile phase consisting of 0.10M sodium dodecyl …Read More »
A pilot study recently published in the Journal of Drugs in Dermatology shows that a combination of salicylic acid and botanical extracts can reduce erythema associated with mild acne. Researchers combined an over-the-counter topical gel containing 2 percent salicylic acid combined with botanicals that have been known to have anti-inflammatory properties. This …Read More »
DOI: 1203475417698697 PMID: 28903585 Liu CW, Reed A, Sisic M, Tan JRead More »
Quality of Life Measurement in Acne. Position Paper of the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS).
DOI: jdv.14585 PMID: 28898474 Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment …Read More »