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Acne

Transgender adolescents and acne: A cases series.

DOI: pde.13448  PMID: 29575091   We describe the difficulties of treating acne in a series of female-to-male transgender adolescents, including concerns about potential hepatotoxicity with concomitant use of testosterone with isotretinoin or tetracyclines. Acne is a foreseeable adverse effect of testosterone treatment in transgender adolescents, so monitoring for acne is advised. The treatment of acne in transgender …

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Th17/Treg imbalance in hidradentitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking, and autoimmune comorbidities.

DOI: bjd.16561  PMID: 29573406   Disintegration of the infundibula of terminal hair follicles (HF) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin 17 and local increase in the ratio of proinflammatory Th17 cells and antiinflammatory regulatory …

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Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients.

DOI: S0392-0488.17.05742-X  PMID: 29564872   Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side …

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The Use of Hormonal Antiandrogen Therapy in Female Patients with Acne: A 10-Year Retrospective Study.

DOI: s40257-018-0349-6  PMID: 29556985   Little is known about how dermatologists prescribe hormonal antiandrogen acne treatment (HAAT).The aim of this study was to investigate dermatologists’ HAAT-prescribing habits and HAAT’s impact on systemic antibiotic use in women with acne.We performed a retrospective study at an academic medical center of female patients receiving HAAT …

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‘Disease, illness, affliction? Don’t know’: Ambivalence and ambiguity in the narratives of young people about having acne.

DOI: 1363459318762035  PMID: 29552892   The popular characterisation of acne as a mundane and insignificant feature of adolescence sits at odds with academic studies showing the detrimental impacts of the condition on people of various ages. Drawing from in-depth qualitative interviews with 13- to 25-year olds living in England, this article will …

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Isolation and Identification of the Follicular Microbiome: Implications for Acne Research.

DOI: j.jid.2018.02.038  PMID: 29548797   Our understanding of the microbiome and the role of P. acnes in skin homeostasis and acne pathogenesis is evolving. Multiple methods for sampling and identifying the skin’s microbiome exist and understanding the differences between the abilities of various methods to characterize the microbial landscape is warranted. This …

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Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison.

DOI: s40257-018-0352-y  PMID: 29549588   Very few clinical trials have investigated the effect of topical acne treatment on scarring.Our objective was to evaluate the efficacy of adapalene 0.3%/benzoyl peroxide 2.5% gel (A0.3/BPO2.5) in atrophic acne scar formation in patients with acne.In this multicenter, randomized, investigator-blinded, vehicle-controlled study, subjects with moderate or severe …

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Adapalene 0.3% Gel Shows Efficacy for the Treatment of Atrophic Acne Scars.

DOI: s13555-018-0231-8  PMID: 29549598   Scarring is an unfortunate clinical outcome of acne. Current treatment options for atrophic acne scars are dominated by non-pharmacological, invasive procedures which may not be suitable or affordable to all patients. This phase II, single-center, open-label, exploratory study assessed the efficacy, safety and subject-reported outcomes of adapalene …

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