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Novel combination for the treatment of acne differentiated according to gender: a new step towards personalized treatment.

DOI: S0392-0488.18.05710-3  PMID: 29417793  

The aim of this study is to evaluate efficacy and tolerability of a complete skin care line consisting of an oral supplement in two distinct formulations for males and females, and a topical cream device in the treatment of mild and moderate acne. Oral supplements contain biotin, probiotic, vitamin E, zinc, nicotinamide; in the formulation for males beta sitosterol and boswella serrata were added, the oral supplement for females contains myo-inositol and folic acid. The topical cream device is represented by the association between active plant agents (verbascoside, ocimum gratissimum) and keratolytic molecules (salicylic acid, gluconolactone, complex alpha-hydroxy acids).An equal number of male and female patients with mild to moderate acne were enrolled in a double-blinded clinical trial. Efficacy and tolerability evaluations were performed at week 4 (T1) and week 12 (T2) by Global acne Grading System (GAGs).Most of patients had satisfactory therapeutic response, in terms of GAGs reduction.. All the four groups presented a statistically significant improvement of the mean GAGs at T2 but those assuming the oral supplement improved more, as expected.Our data suggest that this association can be considered a new effective option for mild and moderate acne. This therapeutic line differs from others in the gender matched oral treatment.

Tolino E,  Skroza N,  Mambrin A,  Bernardini N,  Zuber S,  Balduzzi V,  Marchesiello A,  Proietti I,  Potenza C

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DOI: CCID.S137794  PMCID: PMC5798558  PMID: 29440921   Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which …

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