DOI: bjd.16655 PMID: 29624645
Alterations of skin surface lipid (SSL) are believed to be one important factor of acne pathogenesis and SSL plays a key role in the initiation of the acne lesions. In this study, a powerful analytical technique, UPLC-QTOF-MS, was used to investigate the SSL variations of lipid main classes, subclasses and individual species. A total of 70 subjects (35 acne patients and 35 controls) were selected for this study. Multivariate data analysis showed significant differences between two groups. Significant increased levels of 3 main classes of glycerophospholipids, fatty acyls, and sterol lipids and significant decreased levels of 2 main classes of prenol lipids and saccharolipids were monitored in acne patients. Subsequent analysis showed that there were 18 subclasses significantly varied and shared the same changing trends of their belonging main classes. Multivariate data analysis indicated that 36 entities were the most important individual species responsible for the discrimination and phosphatidylserines were the majority of differentiating lipid species. In addition, the reduction of ceramides chain length and increase in unsaturated free fatty acids, contributed to an altered lipid organization and decreased skin barrier function in acne patients. This article is protected by copyright. All rights reserved.
Gan Y, Zhou M, He C, Chen Z, Jia Y