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Inocoterone and acne. The effect of a topical antiandrogen: results of a multicenter clinical trial.

PMID: 1387778  

Because acne is androgen dependent, antiandrogen therapy might improve the condition. Inocoterone acetate (RU 882) is a nonsteroidal antiandrogen that binds to the androgen receptor and has antiandrogenic activity in animal models. To test its topical effect on acne, 126 male subjects with facial acne completed a 16-week, multi-center, double-blind study in which the twice-daily application of a 10% solution of inocoterone was compared with vehicle solution. Baseline and monthly examinations included acne lesion counts and general and endocrine laboratory tests.

Lookingbill DP,  Abrams BB,  Ellis CN,  Jegasothy BV,  Lucky AW,  Ortiz-Ferrer LC,  Savin RC,  Shupack JL,  Stiller MJ,  Zone JJ

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