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No increased rate of hyperkalemia in women taking spironolactone for acne

Young women taking spironolactone for hormonally mediated acne do not need to be monitored for hyperkalemia, say the authors of a study that showed no significant increase in the risk of the condition.

The retrospective study in 974 otherwise healthy women taking spironolactone found the rate of hyperkalemia was 0.72%, compared with 0.76% in women not taking spironolactone, according to data published online March 22 in JAMA Dermatology.

A subset of 13 patients were found to have elevated serum potassium but upon repeat testing in 6, these measurements had all returned to normal, suggesting either incorrect first measurements or that the mild hyperkalemia was transient (JAMA Dermatology 2015[doi:10.1001/jamadermatol.2015.34].

“The low rate of hyperkalemia may encourage more health care professionals to consider the use of this highly effective drug in their clinical practice,” wrote Dr. Molly Plovanich and her coauthors from Brigham and Women’s Hospital and Harvard Medical School, both in Boston.

About Dr. J. Kim

Dr Kim developed (and is continuing to develop) dermatology research news as we way from dermatologists to stay on top of the latest advances in the field of dermatology.

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