Female patients with hormonal acne that typically flares before or after menstrual cycles may be ideal candidates for spironolactone, said Emmy M. Graber, M.D., president of the Dermatology Institute of Boston who spoke on the use of spironolactone for acne on Friday at the American Academy of Dermatology (AAD) annual meeting in San Diego. Spironolactone …Read More »
DOI: bjd.16655 PMID: 29624645 Alterations of skin surface lipid (SSL) are believed to be one important factor of acne pathogenesis and SSL plays a key role in the initiation of the acne lesions. In this study, a powerful analytical technique, UPLC-QTOF-MS, was used to investigate the SSL variations of lipid main …Read More »
Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population.
DOI: ada.2018.73162 PMCID: PMC5872244 PMID: 29610568 Several studies have reported that the V89L and TA repeat polymorphisms [(TA)n] of the SRD5A2 gene were associated with SRD5A2 activity. The activity of dihydrotestosterone, which is converted from testosterone by SRD5A2, is responsible for sebum secretion and the formation of acne. We hypothesized that abnormalities …Read More »
DOI: 1346-8138.14314 PMID: 29611225 Acne vulgaris is a common disease among people in Asia. International guidelines and treatment recommendations emphasize the central role of topical retinoids in the management of acne. However, topical retinoids remain underutilized in clinical practise, which may be in part due to fear of retinoid-associated dermatitis/lack of …Read More »
Indicators of phagocytosis in women with acne during comprehensive treatment that included immunotherapy and probiotics.
PMID: 29602922 Introduction: Acne is one of the most common dermatological diseases. It may have a chronic course, leaving permanent marks, and in last years has been tending to have more and more severe clinical course with widespread skin lesions. According to recent studies, the development of acne is due …Read More »
PMID: 29601613 Surveying identical twins allows us to qualitatively separate genetic and environmental factors that may contribute to acne severity.To study a cohort of identical and fraternal twins to identify environmental factors that may influence acne severity.A survey was administered to 139 identical and fraternal twin multiples (279 subjects) at …Read More »
DOI: s40257-018-0345-x PMID: 29594974 As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses …Read More »
Prospective Controlled Trial for the Treatment of Acne Keloidalis Nuchae With a Long-Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet Laser.
DOI: 1203475417739846 PMID: 29587518 Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with limited interventions of both high efficacy and low morbidity.To assess the efficacy of the long-pulsed 1064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser and topical steroids as a treatment for AKN compared to topical steroids alone.We conducted a single-blinded, randomised, …Read More »
No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles.
DOI: exd.13544 PMID: 29582469 Abnormal hyperkeratinization in sebaceous hair follicles has long been believed to play an important role in acne pathogenesis. Several early reports purported to provide histological evidence for hyperproliferation of keratinocytes in acne lesions by showing a higher expression of the Ki67 as well as certain keratins. The …Read More »
The in vitro antimicrobial evaluation of commercially essential oils and their combinations against acne.
DOI: ics.12456 PMID: 29574906 The study investigated the efficacy of commercial essential oil combinations against the two pathogens responsible for acne with the aim to identify synergy and favourable oils to possibly use in a blend.Antimicrobial activity was assessed using the minimum inhibitory concentration (MIC) assay against Staphylococcus epidermidis (ATCC 2223) …Read More »