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Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab.

PMID: 29447652   PASH syndrome (pyoderma gangrenosum, acne, and suppurative hidradenitis) forms part of the spectrum of autoinflammatory diseases. We report an unusual case of PASH syndrome in a patient with end-stagerenal disease (ESRD) who was successfully treated with the tumor necrosis factor inhibitor, adalimumab. The case underscores the challenges associatedwith …

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The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis.

DOI: jdv.14881  PMID: 29444375   Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence …

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Adult-onset acne: prevalence, impact, and management challenges.

DOI: CCID.S137794  PMCID: PMC5798558  PMID: 29440921   Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. In contrast to …

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Formulation And In-Vitro And Ex-Vivo Evaluation Of Tretinoin Loaded Cubosomal Gel For Acne Treatment.

DOI: 1872211312666180213121117  PMID: 29437029   The current work was attempted to formulate and evaluate the topical sustained release delivery systems potential of bicontinuous cubic monoglyceride -water phases – ‘cubosomes’ containing Tretinoin with an opinion to sustain the release of drug in the acne treatment.Tretinoin loaded cubosomes were prepared by bottom-up technique, by …

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A Qualitative Investigation of the Impact of Acne on Health-Related Quality of Life (HRQL): Development of a Conceptual Model.

DOI: s13555-018-0224-7  PMID: 29435857   The negative impact of acne on aspects of health-related quality of life (HRQL) has been demonstrated in many quantitative studies; however, there has been relatively little qualitative research exploring the impact of acne and the use of topical treatment. The study aimed to explore the impact of …

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Topical Delivery of Erythromycin Through Cubosomes For Acne.

DOI: 2211738506666180209100222  PMID: 29424323   Topical delivery is an attractive route for local and systemic treatment. Novel topical application has many advantages like avoids the GI-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug over the conventional dosage forms. The aim of present work was …

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Efficacy of Intense-pulsed Light Therapy with Topical Benzoyl Peroxide 5% versus Benzoyl Peroxide 5% Alone in Mild-to-moderate Acne Vulgaris: A Randomized Controlled Trial.

DOI: jrpp.JRPP_17_29  PMCID: PMC5787904  PMID: 29417078   Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients’ social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) …

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Comparing the Efficacy of Low Dose and Conventional Dose of Oral Isotretinoin in Treatment of Moderate and Severe Acne Vulgaris.

DOI: jrpp.JRPP_17_30  PMCID: PMC5787910  PMID: 29417084   This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment …

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