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Spironolactone for hormonal acne

Spironolactone

Female patients with hormonal acne that typically flares before or after menstrual cycles may be ideal candidates for spironolactone, said Emmy M. Graber, M.D., president of the Dermatology Institute of Boston who spoke on the use of spironolactone for acne on Friday at the American Academy of Dermatology (AAD) annual meeting in San Diego. Spironolactone …

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Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population.

DOI: ada.2018.73162  PMCID: PMC5872244  PMID: 29610568   Several studies have reported that the V89L and TA repeat polymorphisms [(TA)n] of the SRD5A2 gene were associated with SRD5A2 activity. The activity of dihydrotestosterone, which is converted from testosterone by SRD5A2, is responsible for sebum secretion and the formation of acne. We hypothesized that abnormalities …

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Optimizing the use of topical retinoids in Asian acne patients.

DOI: 1346-8138.14314  PMID: 29611225   Acne vulgaris is a common disease among people in Asia. International guidelines and treatment recommendations emphasize the central role of topical retinoids in the management of acne. However, topical retinoids remain underutilized in clinical practise, which may be in part due to fear of retinoid-associated dermatitis/lack of …

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An Acne Survey from the World’s Largest Annual Gathering of Twins.

PMID: 29601613   Surveying identical twins allows us to qualitatively separate genetic and environmental factors that may contribute to acne severity.To study a cohort of identical and fraternal twins to identify environmental factors that may influence acne severity.A survey was administered to 139 identical and fraternal twin multiples (279 subjects) at …

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Emerging Therapies for Acne Vulgaris.

DOI: s40257-018-0345-x  PMID: 29594974   As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses …

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Prospective Controlled Trial for the Treatment of Acne Keloidalis Nuchae With a Long-Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet Laser.

DOI: 1203475417739846  PMID: 29587518   Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with limited interventions of both high efficacy and low morbidity.To assess the efficacy of the long-pulsed 1064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser and topical steroids as a treatment for AKN compared to topical steroids alone.We conducted a single-blinded, randomised, …

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No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles.

DOI: exd.13544  PMID: 29582469   Abnormal hyperkeratinization in sebaceous hair follicles has long been believed to play an important role in acne pathogenesis. Several early reports purported to provide histological evidence for hyperproliferation of keratinocytes in acne lesions by showing a higher expression of the Ki67 as well as certain keratins. The …

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The in vitro antimicrobial evaluation of commercially essential oils and their combinations against acne.

DOI: ics.12456  PMID: 29574906   The study investigated the efficacy of commercial essential oil combinations against the two pathogens responsible for acne with the aim to identify synergy and favourable oils to possibly use in a blend.Antimicrobial activity was assessed using the minimum inhibitory concentration (MIC) assay against Staphylococcus epidermidis (ATCC 2223) …

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