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Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris.

DOI: j.jid.2017.01.026  PMID: 28647025   Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Olumacostat glasaretil-mediated sebum suppression may …

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Development and validation of IHS4, a novel dynamic scoring system to assess hidradenitis suppurativa/acne inversa severity.

DOI: bjd.15748  PMID: 28636793   A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. Zouboulis CC,  Tzellos T,  Kyrgidis A,  Jemec GBE,  Bechara FG,  Giamarellos-Bourboulis EJ,  Ingram JR,  Kanni T,  Karagiannidis I,  Martorell A,  Matusiak Ł,  Pinter A,  Prens EP,  Presser D,  Schneider-Burrus S,  von Stebut E,  Szepietowski …

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Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial.

DOI: s12906-017-1813-1  PMCID: PMC5474046  PMID: 28623918   The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to …

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Anti-acne drugs in phase 1 and 2 clinical trials.

DOI: 13543784.2017.1337745  PMID: 28627277   Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the …

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Oxidative stress and psychiatric morbidity in patients with facial acne.

DOI: jocd.12366  PMID: 28631890   Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. Awad SM,  Morsy H,  Sayed AA,  Mohamed NA,  Ezzat GM,  Noaman MM

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